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Year : 2020  |  Volume : 29  |  Issue : 2  |  Page : 234-238

Serum cytokine profile (Interleukin-6) among women with pelvic organ prolapse

1 National Obstetric Fistula Centre, Abakaliki, Nigeria
2 National Obstetric Fistula Centre, Abakaliki; Department of Obstetrics and Gynaecology, University of Benin Teaching Hospital, Benin City, Nigeria
3 Federal Teaching Hospital, Abakaliki, Nigeria

Correspondence Address:
Dr. Maradona E Isikhuemen
Department of Obstetrics and Gynaecology, University of Benin Teaching Hospital, Benin City
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/NJM.NJM_47_20

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Background: Pelvic organ prolapse (POP) is a common gynecological problem, particularly in the grand multipara. There are indications that serum concentration of cytokines is higher in women with POP and even more so when there is evidence of infection. This study assesses the serum cytokine level (interleukin [IL]-6) in women with POP. Materials and Methods: This study was conducted among 96 women with POP and a control group of 96 women. A case–control study using a quota system nonprobability sampling technique was done. The serum cytokine level was determined using a commercial standard enzyme-linked immunosorbent assay kit. Results: The mean age and parity were 53.54 ± 10.1 years and 7.04 ± 2.33, respectively. The mean level of serum IL-6 and standard error of mean was 95.79 ± 18.6, ±1.9 as against 17.92 ± 7.62, ±0.78 for control and as against <20 pg/ml for the general population.P values were 0.00 and 0.08, respectively. The result showed that IL-6 was significantly increased in women with POP. Conclusion: This study suggests that cytokine levels were significantly elevated in patients with POP.

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