Nigerian Journal of Medicine

ORIGINAL ARTICLE
Year
: 2022  |  Volume : 31  |  Issue : 4  |  Page : 374--377

Comparative Study of Bisacodyl Suppository Plus Antibiotics versus Antibiotics Alone in the Prevention of Postprostate Biopsy Infection


Odo Chinonso1, Anselm Okwudili Obi1, Timothy Uzoma Mbaeri2, Ahuizechukwu Emmanuel Obiesie2, Ulebe Augustine Obasi1, John Chike Okeke1, Joseph Amauzo Abiahu2, Alexander Maduaburochukwu Ekwunife Nwofor2 
1 Department of Surgery, Alex-Ekwueme Federal University Teaching Hospital Abakaliki, Abakaliki, Ebonyi State, Nigeria
2 Department of Surgery, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nnewi, Anambra State, Nigeria

Correspondence Address:
Odo Chinonso
Department of Surgery, Alex-Ekwueme Federal University Teaching Hospital Abakaliki, Abakaliki, Ebonyi State
Nigeria

Aims: The purpose of this study is to determine whether bisacodyl rectal suppository can reduce infective complications postprostate biopsy. Patients, Materials and Methods: This was a comparative cross-sectional study done at the urology unit of a tertiary hospital over 12 months. A sample size of 56 was determined using Fisher's formula. Both groups had tablets of ciprofloxacin 500 mg and metronidazole 400 mg at induction of anaesthesia and continued for three days postbiopsy at a dose of 500 mg twice daily and 400 mg thrice daily, respectively. In addition to antibiotics, those in Group 1 had 20 mg of bisacodyl (Dulcolax) suppositories given at night, starting two days before the procedure. The patients underwent digitally guided 10-core transrectal prostate biopsy on an outpatient basis. Blood and urine samples were taken for full blood count and urine culture, respectively, before surgery and three days after the biopsy. Statistical analysis was performed using the SPSS version 21.0. The level of significance was set at P < 0.05. Results: The mean age was 69.64 ± 9.31 with a range of 52–90 years. The peak age distribution was 70–79. In Group 1, two patients had urosepsis, one patient had urinary tract infection (UTI), and seven patients had bacteriuria, while in Group 2, four patients had urosepsis, four patients had UTI, and ten patients had bacteriuria. Conclusions: The addition of bisacodyl rectal suppository to antibiotics reduced the frequency of infective complications following prostate biopsy. The observed difference, however, was not statistically significant.


How to cite this article:
Chinonso O, Obi AO, Mbaeri TU, Obiesie AE, Obasi UA, Okeke JC, Abiahu JA, Ekwunife Nwofor AM. Comparative Study of Bisacodyl Suppository Plus Antibiotics versus Antibiotics Alone in the Prevention of Postprostate Biopsy Infection.Niger J Med 2022;31:374-377


How to cite this URL:
Chinonso O, Obi AO, Mbaeri TU, Obiesie AE, Obasi UA, Okeke JC, Abiahu JA, Ekwunife Nwofor AM. Comparative Study of Bisacodyl Suppository Plus Antibiotics versus Antibiotics Alone in the Prevention of Postprostate Biopsy Infection. Niger J Med [serial online] 2022 [cited 2022 Oct 5 ];31:374-377
Available from: http://www.njmonline.org/article.asp?issn=1115-2613;year=2022;volume=31;issue=4;spage=374;epage=377;aulast=Chinonso;type=0